![]() a liver transplant, which is used to treat some cases of familial ATTR amyloidosis.If you have ATTR amyloidosis, your doctor’s recommended treatment plan will depend on the specific type you have, as well as the organs that are affected and the symptoms that develop.ĭepending on your diagnosis, they may prescribe one or more of the following: It’s usually triggered by an infection or inflammatory disease, such as rheumatoid arthritis. It involves a protein known as serum amyloid A. It involves abnormal antibody components, known as light chains.ĪA amyloidosis is also called secondary amyloidosis. These types involve different proteins than ATTR amyloidosis.ĪL amyloidosis is also known as primary amyloidosis. Several other types of amyloidosis also exist, including AL and AA amyloidosis. This type of ATTR amyloidosis typically affects men over the age of 70 years old. Those fibrils are most commonly deposited in the heart. In this type of ATTR amyloidosis, TTR becomes less stable with age and begins to form amyloid fibrils. Instead, it develops as a result of aging processes. Wild-type ATTR amyloidosis isn’t caused by any known genetic mutations. Symptoms of familial ATTR amyloidosis start in adulthood and get worse over time. Depending on the specific genetic mutation that a person has, the condition may affect their nerves, their heart, or both. Many different genetic mutations may cause familial ATTR amyloidosis. This raises the chances that TTR will form amyloid fibrils. These genetic mutations cause TTR to be less stable than normal. It’s caused by genetic mutations that may be passed from parent to child. Familial ATTR amyloidosisįamilial ATTR amyloidosis is also known as hereditary ATTR amyloidosis. Other types of amyloidosis may also develop when proteins other than TTR clump into amyloid fibrils. The two main types are familial and wild-type. If you’re living with ATTR amyloidosis, but you’re not sure which type, ask your doctor. The type of ATTR amyloidosis that a person has will affect their long-term outlook. ![]()
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